N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide

N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide is a synthetic small molecule belonging to the class of phenylpyridazines and benzamides. It acts as a potent inhibitor of mitogen‑activated protein kinase 14 (MAPK14, also known as p38α MAPK), with reported IC50 values in the sub-nanomolar range (IC50 ≈ 0.8 nM; Ki ≈ 0.4 nM)[1][5]. This compound has been studied primarily in biochemical and structural biology contexts as a tool compound for probing p38α MAPK function, but there are no records of clinical development or approved therapeutic use[3][4]. No developer or manufacturer is associated with this molecule.

Other names

N-cyclopropyl-4-methyl-3-(1-(2-methylphenyl)-6-phthalazinyl)benzamideBenzamide, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)-6-phthalazinyl]-